Seneca, SC Real Estate
The gateway to Lake Keowee, and the center of Upstate lake life.
Population
~9,300
Median home price
$385K (in-town) · $950K+ (waterfront)
Airport (GSP)
45 min
Clemson
15 min
$529,000
14001 Rhine Court
Seneca, SC
Listing courtesy of Alicia Keys of Clardy Real Estate - Lake Keowee
$1,445,000
123 Pinnacle Pointe Drive
Seneca, SC
Listing courtesy of Alicia Keys of Clardy Real Estate - Lake Keowee
$234,000
623 Post Oak Lane
Seneca, SC
Listing courtesy of Alicia Keys of Clardy Real Estate - Lake Keowee
$315,000
329 Kings Grant Court
Seneca, SC
Listing courtesy of Alicia Keys of Clardy Real Estate - Lake Keowee
$545,000
205 Cross Creek Drive
Seneca, SC
Listing courtesy of Alicia Keys of Clardy Real Estate - Lake Keowee
$1,750,000
142 W Bay View Drive
Seneca, SC
Listing courtesy of Fran Graham of Howard Hanna Allen Tate - Lake Keowee Seneca
Active Under Contract$2,145,000
314 Longwood Drive
Seneca, SC
Listing courtesy of Melanie Fink of Howard Hanna Allen Tate - Melanie Fink & Assoc
$3,495,000
122 S Oak Pointe Drive
Seneca, SC
Listing courtesy of Gregory Coutu of Howard Hanna Allen Tate - Lake Keowee Seneca
$569,000
436 Cane Creek Landing
Seneca, SC
Listing courtesy of Regina Bolt of Clardy Real Estate
Active Under Contract$1,125,000
512 Dye Drive
Seneca, SC
Listing courtesy of Teara Barnwell of Clardy Real Estate - W Union
$2,585,000
357 Stardust Lane
Seneca, SC
Listing courtesy of Ralph Harvey, III of ListWithFreedom.com
Open House$1,150,000
119 Grand Summit Drive
Seneca, SC
Listing courtesy of Fran Graham of Howard Hanna Allen Tate - Lake Keowee Seneca
© 2026 Western Upstate MLS (UMLS). All rights reserved. The data relating to real estate for sale on this web site comes in part from the Internet Data Exchange Program of UMLS. Real estate listings held by IDX Brokerage firms other than Clardy Real Estate are marked with the Internet Data Exchange logo or the Internet Data Exchange thumbnail logo and detailed information about them includes the name of the listing Brokers. The data relating to real estate for sale on this Web site comes in part from the Broker Reciprocity Program of the Western Upstate Association of REALTORS®, Inc. and the Western Upstate Multiple Listing Service, Inc. Information provided is deemed reliable but not guaranteed. Data last updated: Sunday, November 1st, 2026 at 02:27:50 PM. Data services provided by IDX Broker
Seneca sits at the crossroads of Lake Keowee, Lake Hartwell, and Clemson, making it the most connected town on the Upstate lake circuit. Historic Ram Cat Alley anchors a walkable downtown with restaurants, shops, and live music, and Prisma Health Oconee Memorial keeps healthcare close. For buyers who want both a real town and easy access to the water, Seneca is the default answer.
Downtown Seneca is one of the most walkable small-town centers in Upstate SC. Ram Cat Alley alone anchors a dozen restaurants, a brewery, a wine bar, and regular live music, and Norton-Thompson Park adds green space right off the strip.
For families, Seneca has both public schools inside the Oconee County district and a handful of private options. Prisma Oconee Memorial keeps a full hospital in town, and specialty care is a 45-minute drive down 123 to Greenville.
For buyers on the lake, Seneca gives you the most flexibility: you can live on the Keowee shoreline five minutes from downtown, or on Lake Hartwell in South Cove, or in a golf community, or in-town on a corner lot. Every housing style is here.
Central location
Closest town to Lake Keowee, Lake Hartwell, Clemson, and the medical center. Nothing is more than 20 minutes.
True walkable downtown
Ram Cat Alley + Main Street are a legit small-city center, not a strip mall.
Full range of price points
From $250K in-town cottages to $5M+ waterfront estates. Every buyer is served here.
Best healthcare access on the lake
Prisma Oconee Memorial anchors a growing medical district.
A few of the notable neighborhoods and communities you\u2019ll shop in Seneca.
Local knowledge you can\u2019t Google
Alicia was born and raised in the Upstate. She lives on Lake Keowee. She\u2019ll tour you through Seneca with the real story, not the marketing copy.